An experimental study was conducted to evaluate the protective effect of herbal methionine and Mangifera indica on lead-induced cardiotoxicity in broiler chicks. Male broiler chicks (Cobb strain) of day-old age were randomly divided into six groups consisting of fifteen in each group. Group 1 was maintained as basal diet control and 2 was kept on lead @ 300 ppm in feed throughout 5 wks as toxic control without any treatment. Groups 3 and 4 were maintained respectively on herbal methionine @ 1.4 gm/ kg feed + Mangifera indica @ 0.1% in feed. Group 5 and 6 were treated with lead + herbal methionine and lead + Mangifera indica, respectively for the 5 wks. The concentration of thiobarbituric acid reacting substances (TBARS) and protein carbonyls revealed a significant (P <0.05) increase, while the activity of superoxide dismutase (SOD), catalase and ATPases, and the concentration of reduced glutathione (GSH) revealed a significant (P < 0.05) decrease in the lead toxic control group 2. Treatment with herbal remedies in groups 5 and 6 resulted in a marked improvement in all the above parameters as compared to those of lead toxic control. Thus, it is concluded that lead-induced cardiotoxicity is attributed to oxidative stress and the herbs in test offered better amelioration. The beneficial effects of herbal methionine and Mangifera indica may be attributed to their antioxidant, anti-stress and cardio-protective principles.
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